Arsenic, cadmium, chromium and nickel in cancerous and healthy tissues from patients with head and neck cancer.
Identifieur interne : 000137 ( Main/Exploration ); précédent : 000136; suivant : 000138Arsenic, cadmium, chromium and nickel in cancerous and healthy tissues from patients with head and neck cancer.
Auteurs : Rim Khlifi [Tunisie] ; Pablo Olmedo ; Fernando Gil ; Bouthaina Hammami ; Amine Chakroun ; Ahmed Rebai ; Amel Hamza-ChaffaiSource :
- The Science of the total environment [ 1879-1026 ] ; 2013.
Descripteurs français
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- Adult, Arsenic (analysis), Cadmium (analysis), Carcinoma, Squamous Cell (etiology), Carcinoma, Squamous Cell (metabolism), Carcinoma, Squamous Cell (pathology), Chromium (analysis), Female, Head and Neck Neoplasms (etiology), Head and Neck Neoplasms (metabolism), Head and Neck Neoplasms (pathology), Humans, Male, Middle Aged, Nickel (analysis), Occupational Exposure (adverse effects), Occupational Exposure (analysis), Smoking, Spectrophotometry, Atomic, Tunisia.
- MESH :
- chemical , analysis : Arsenic, Cadmium, Chromium, Nickel.
- geographic : Tunisia.
- adverse effects : Occupational Exposure.
- analysis : Occupational Exposure.
- etiology : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- metabolism : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- pathology : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- Adult, Female, Humans, Male, Middle Aged, Smoking, Spectrophotometry, Atomic.
Abstract
Chronic exposure to heavy metals has long been recognized as being capable to increase head and neck cancer incidence among exposed human populations. Head and neck cancer is a significant public health issue in Tunisia. The aim of the present study was to evaluate the concentrations of As, Cd, Cr and Ni in healthy and tumor tissues of head and neck cancer patients. Metal concentrations were determined in tumor and healthy tissues of 101 head and neck cancer patients, using Atomic Absorption Spectrometry. The As, Cd, Cr, and Ni levels in tumor tissues were 3.4, 2.5, 1.3 and 1.5 times higher than those of healthy tissues (p<0.05), respectively. Tumor tissue metal levels were higher in men than in women. As and Cd levels in tumor and healthy tissue samples of patients smokers are significantly higher than those of non-smokers (p<0.05). A strong effect of cumulative smoking as expressed in the number of pack per year, and tumor tissue Cd levels were positively associated with three groups of age (<40, 51-60 and >60 years) in both never-smokers and ever-smokers (<20 and ≥20 pack per year). Healthy tissue Cd levels were negatively associated with age in those three groups of smokers. The highest Cd and Cr concentrations among both workers and non-workers were observed in tumor tissues. The Cd and Cr in tissues of farmers, bricklayers and painters were all significantly higher among the workers as compared with the non-workers group. Tissue metal levels have increased due to smoking and occupational exposure. Heavy metal exposure via tobacco smoking and occupational exposures may increase the risk of head and neck in the Tunisian population.
DOI: 10.1016/j.scitotenv.2013.02.050
PubMed: 23500399
Affiliations:
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Le document en format XML
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Ecotoxicology, Sfax University, IPEIS, Sfax</wicri:regionArea><wicri:noRegion>Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name></author><author><name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name></author><author><name sortKey="Hammami, Bouthaina" sort="Hammami, Bouthaina" uniqKey="Hammami B" first="Bouthaina" last="Hammami">Bouthaina Hammami</name></author><author><name sortKey="Chakroun, Amine" sort="Chakroun, Amine" uniqKey="Chakroun A" first="Amine" last="Chakroun">Amine Chakroun</name></author><author><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name></author><author><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name></author></analytic><series><title level="j">The Science of the total environment</title><idno type="eISSN">1879-1026</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Arsenic (analysis)</term><term>Cadmium (analysis)</term><term>Carcinoma, Squamous Cell (etiology)</term><term>Carcinoma, Squamous Cell (metabolism)</term><term>Carcinoma, Squamous Cell (pathology)</term><term>Chromium (analysis)</term><term>Female</term><term>Head and Neck Neoplasms (etiology)</term><term>Head and Neck Neoplasms (metabolism)</term><term>Head and Neck Neoplasms (pathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nickel (analysis)</term><term>Occupational Exposure (adverse effects)</term><term>Occupational Exposure (analysis)</term><term>Smoking</term><term>Spectrophotometry, Atomic</term><term>Tunisia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Arsenic</term><term>Cadmium</term><term>Chromium</term><term>Nickel</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Tunisia</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Smoking</term><term>Spectrophotometry, Atomic</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chronic exposure to heavy metals has long been recognized as being capable to increase head and neck cancer incidence among exposed human populations. Head and neck cancer is a significant public health issue in Tunisia. The aim of the present study was to evaluate the concentrations of As, Cd, Cr and Ni in healthy and tumor tissues of head and neck cancer patients. Metal concentrations were determined in tumor and healthy tissues of 101 head and neck cancer patients, using Atomic Absorption Spectrometry. The As, Cd, Cr, and Ni levels in tumor tissues were 3.4, 2.5, 1.3 and 1.5 times higher than those of healthy tissues (p<0.05), respectively. Tumor tissue metal levels were higher in men than in women. As and Cd levels in tumor and healthy tissue samples of patients smokers are significantly higher than those of non-smokers (p<0.05). A strong effect of cumulative smoking as expressed in the number of pack per year, and tumor tissue Cd levels were positively associated with three groups of age (<40, 51-60 and >60 years) in both never-smokers and ever-smokers (<20 and ≥20 pack per year). Healthy tissue Cd levels were negatively associated with age in those three groups of smokers. The highest Cd and Cr concentrations among both workers and non-workers were observed in tumor tissues. The Cd and Cr in tissues of farmers, bricklayers and painters were all significantly higher among the workers as compared with the non-workers group. Tissue metal levels have increased due to smoking and occupational exposure. Heavy metal exposure via tobacco smoking and occupational exposures may increase the risk of head and neck in the Tunisian population.</div></front></TEI><affiliations><list><country><li>Tunisie</li></country></list><tree><noCountry><name sortKey="Chakroun, Amine" sort="Chakroun, Amine" uniqKey="Chakroun A" first="Amine" last="Chakroun">Amine Chakroun</name><name sortKey="Gil, Fernando" sort="Gil, Fernando" uniqKey="Gil F" first="Fernando" last="Gil">Fernando Gil</name><name sortKey="Hammami, Bouthaina" sort="Hammami, Bouthaina" uniqKey="Hammami B" first="Bouthaina" last="Hammami">Bouthaina Hammami</name><name sortKey="Hamza Chaffai, Amel" sort="Hamza Chaffai, Amel" uniqKey="Hamza Chaffai A" first="Amel" last="Hamza-Chaffai">Amel Hamza-Chaffai</name><name sortKey="Olmedo, Pablo" sort="Olmedo, Pablo" uniqKey="Olmedo P" first="Pablo" last="Olmedo">Pablo Olmedo</name><name sortKey="Rebai, Ahmed" sort="Rebai, Ahmed" uniqKey="Rebai A" first="Ahmed" last="Rebai">Ahmed Rebai</name></noCountry><country name="Tunisie"><noRegion><name sortKey="Khlifi, Rim" sort="Khlifi, Rim" uniqKey="Khlifi R" first="Rim" last="Khlifi">Rim Khlifi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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